I have this exact same issue. It started occurring directly after I installed the Window 10 Fall Creator's Update. Reinstalling Musicbee, either on top of the existing install or with a clean install of Musicbee, results in it being able to open once, but if it is closed and you try to reopen it, nothing happens. Rebooting Windows does doesn't help, running as administrator does nothing, and no other programs have had issues due to the FCU.