my 2 cents:
1.
Personally I would be a little bit surprised if a bios update alone would solve these strange issues.
But I would for sure update such an old bios anyway.
2.
Then don't forget to go into the bios menu, and go through all available options to see if you may want or need to tweak some things.
3.
After that my suggestion would be to do a clean Windows 10 install, so that it will be using information that the new bios provides to the OS when it is installing itself.
4.
Install Intel's Chipset INF Utility
https://www.intel.com/content/www/us/en/download/19347/chipset-inf-utility.html5.
Then install Intel's Management Engine Drivers
https://www.intel.com/content/www/us/en/download/682431/intel-management-engine-drivers-for-windows-10-and-windows-11.html?wapkw=mei(they are more recent than the versions that Asus has on their website. It's not uncommon that at a certain point in time mobo manufacturors stop updating the downloads for their motherboards)
Optional:
6.
Check if there are firmware updates for your SSDs that may solve known issues:
https://eu.crucial.com/support/ssd-support7.
find and update drivers for your graphics, audio and possibly other devices.
(optional because Windows 10 is doing a pretty good job in finding the best and most stable drivers automatically)
8.
The support page for your motherboard also offers an 'Intel Rapid Storage Technology Driver'
I don't think that should be used anymore since I recall that Windows 10 already has a more recent version these days.
Important
You should read this first about the MEupdate tool that's also listed on the ASUS site - intel-me-and-bios-updates-general-advice
It says this -
"You should always update Intel's Windows drivers (MEI drivers) and ME firmware BEFORE updating the BIOS".
Sorry I didn't post that originally, I've never had to deal with intel ME before so I had to do some reading first.
That surprises me a little bit.
I was always convinced that first the bios should be updated, and after that any possible system drivers/firmware.
That advise seems to come from an individual, and may pertain to the motherboard and drivers described there?
I myself would be doing some more research, and possibly find recommendations by Asus or Intel before I would change the order I am suggesting above.
PS
@Phred, would it be an idea to split this topic into a new one?
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edit
I may be confusing Intel's Management Engine Drivers and Asus's MEUpdateTool.
Perhaps the latter should be installed first, then update the bios, and then install Intel's ME drivers?
The wisest thing to do before proceeding is probably to post this question on a forum that is about Asus motherboards.
The people over there will probably be able to give you the best advice for this situation/motherboard.