Maybe I'm crazy
Of course you can set all the settings manually. ma_t14 is absolutely right about this. But however, many people do not know that messing around with the volume sliders, using DirectSound, normalize volume , replay gain and all those functions, which are definitly nice to have, mean a degression in audio quality. And whatever equipment you have: better quality of the digital music signal will lead to better results in analog sound quality. And this before you face things like hardware jitter correction etc.
Music is all about feeling: And feeling also travels with sound quality. The "Audiophile Mode" would state that there is everything done in MusicBee what can be done to achieve the best sound quality. If you are not satisfied with the sound after that, you can look into new hardware :-). Because in reverse, you don't need to buy new hardware, if you don't have a perfect digital signal.
And after all, those who don't care about audioquality don't have to go into the "Audiophile mode". As everything this is only a suggestion to clarify things for all users connected with audioquality in MusicBee, which is the best Music Manager I know.