Welcome to the forum GaryLC (and Manny)
MusicBee is a highly advanced music player/manager.
So if your friend has (as you said) difficulties reading and navigating through a conventional computer using a mouse and keyboard, setting up and using MusicBee's advanced features is not going to be fun for him.
But, if you are the person that will be doing all the importing, tweaking and adjusting, and setting everything up for him, it should be very doable to create some views and display interfaces that are not to hard to navigate through using a touchscreen.
You could choose larger fonts, album covers display, prepare playlists with icons, etc, and activate a 'party' mode (called Locked Down mode) so the chances of disasters happening during the show are reduced.