Personally I wouldn't use it for a number of reasons.
1 - Uploading (albeit one time) 100+ gb of music to the cloud would take quite a while.
2 - The cost for storing 100+ gb on a cloud server would not be inexpensive.
3 - I already have and use SubSonic. It's available for Mac, Windows, and Linux desktops, along with Android, iPhone, Blackberry, and Windows phones. I can access the music on my home hard drive from anywhere in the world.