There's nothing special about that layout. Here it is in a different skin so you can clearly see the panels (click to enlarge):
From left to right:
· left sidebar
· thumbnail browser
· main panel (top)
· playing track panel (bottom)
· right sidebar (containing 'now playing list' (top) & 'track information' (bottom)
The config for all this is in:
preferences -> layout(1)
The little 'layout' icon beside the search bar.
It's not that hard, and can be fun.