It does work under Wine pretty well but there are a couple of things that don't work as intended, some of which may be due to different packages within your distro or limitations within Wine. On my ArchLinux system the Wave Bar doesn't draw, the blurry album art you get as a background when in thumbnail view doesn't blur, and you can't rip CD's (although you can read them perfectly well). Not having other distros I can't comment on whether these problems are with my system or with the nature of wine getting it to run. It is after all a .NET 4 program which have always been a bit hit and miss with compatibility under wine.
Bottom line, give it a whirl on a clean wine prefix (let the MB installer get dotnet 4) and see what your results are.